Ovary Syndrome: A Randomized Clinical Trial

Background: Since increased LH in the early follicular phase in PCOS patients es-pecially in GnRH antagonist protocol could be associated with reduced oocyte quali-ty and pregnancy and impared implantation. The current study was conducted to de-termine ART outcomes in GnRH antagonist protocol (flexible) and long GnRH ago-nist protocol and compare them with adding GnRH antagonist in GnRH antagonist (flexible) protocol during early follicular phase in patients with polycystic ovary syndrome undergoing ICSI. Methods: In this randomized clinical trial, 150 patients with polycystic ovary syn-drome undergoing ICSI were enrolled from 2012 to 2014 and randomly assigned to receive either GnRH antagonist protocol during early and late follicular phase or GnRH antagonist protocol (flexible) or long GnRH agonist protocol. The clinical and laboratory pregnancy in three groups was determined and compared. In this con-text, the chi-square and Fisher's exact test and ANOVA were used for data analysis. Statistical significance was defined as p<0.05