CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Intensive ALL-type therapy without local radiotherapy provides a 90 % event-free survival for children with T-cell lymphoblastic lymphoma: a BFM Group report

The purpose of our study was to investi-gate the efficacy of an acute lymphoblas-tic leukemia (ALL)-type treatment with moderate-dose, prophylactic cranial irra-diation and without local radiotherapy for childhood T-cell lymphoblastic lymphoma (T-LBL). From April 1990 to March 1995, 105 evaluable patients, 1.1 to 16.4 years of age, with T-LBL were enrolled in study NHL-BFM 90 (non-Hodgkin’s lymphoma– Berlin-Frankfurt-Munster 90). They re-ceived an 8-drug induction over 9 weeks followed by an 8-week consolidation includ-ing methotrexate (MTX) 5 g/m2 3 4. Patients with stage I (n 5 2) and II (n 5 2) continue