Glucose Homeostasis during the Perinatal Period in Normal Rats and Rats with a Glycogen Storage Disorder

during parturition for use as a glucose source until the onset of gluconeogenesis at 2 h after birth. A rat strain (NZRIMh) unable to mobilize liver glycogen because of a phosphorylase b kinase deficiency has been used to assess the importance of liver glycogen in glucose homeostasis of the newborn. In normal rats the mean blood glucose concentration of the fetus measured at various times up to 24 h after natural birth ranged between 3.7 and 5.4 mM. In con-trast, fetuses ofthe affected rats were hypoglycemic be-fore birth (2.02+0.15 mM), and by 1 h after birth the blood glucose had decreased to 0.74±0.14 mM. Con-centrations increased by 4 h to 1.48±0.17 mM and by 24 h reached values not significantly different from the normal newborn rats. Changes in plasma insulin over the perinatal period were similar in both groups al-though concentrations were always significantly lower in the affected rats. The findings demonstrate the crucial role of the fetal liver glycogen store in the maintenance of normogly-cemia in the newborn. The normal rat does not develop hypoglycemia when born naturally and left with the mother after birth (in contrast to other studies in which the newborn were taken by cesarian delivery 1 d pre-maturely and kept in an artificial environment without food). The rats with the glycogen storage disorder ex-perienced severe hypoglycemia without any apparent effects, which raises questions concerning alternative fuels available to and utilized by the newborn