AGE DISCLOSED A DEFINITE TENDENCY FOR THE 17-KETOSTEROID EXCRETION TO DE- CREASE WITH AGE. THIS IS IN ACCORD WITH RECENT FINDINGS OF HAMILTON AND HAM-

^ (10) in 1935 of a color reaction with me-tadinitrobenzene for determination of 17-ke-tosteroids, several reports have been pub-lished concerning the values for the daily excretion of these steroids in the urine of young male adults. Most of these studies have been performed with Callow, Callow, and Emmens ' (3) modification of the Zim-mermann procedure or with closely related methods. The findings are on the whole in good agreement, and it seems to be generally accepted that the normal neutral 17-keto-steroid excretion of men between 20 and 40 years averages 15 mg. daily. A summary of the results obtained by various author