Residues

A water-soluble cyclophane (1) having poly(ethylene glycol) (PEG) moieties has been prepared from a tetraazide-functionalized cyclophane derivative and four poly(ethylene glycol) methyl ether acetylenes by Cu(I)-catalyzed 1,3 dipolar cycloadditions (click chemistry). An analogous de-rivative having a pyrene moiety (2) was also prepared in a similar manner. The guest-binding be-havior of 1 and 2 toward anionic guests such as 6-p-toluidinonaphthalene-2-sulfonate was inves-tigated by fluorescence spectroscopy. The binding constants (K) of the host-guest complexes were evaluated