Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction

MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity. MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered categories of genomic elements that have changed the way we view the diploid genome and added one additional order of complexity in gene expression and regulation. Also, they increased our understanding of the plasticity of the human and other mammalian genomes. miRNAs belong to the most abundant class of smal