Effects of the Organophosphorus Compound, O-ethyl-W-dimethyl-phosphoramidocyanidate (Tabun), on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats. ROMANO,

behavioral effects of acutely administered anti-cholinesterase compound O-ethyl-A'-dimethyl phosphoramidocyanidate (tabun), to male rats was performed in three studies across five dose levels (100-198 MgAg, sc). Doses of 122 jig/kg or greater produced conditioned flavor aversions. Spontaneous locomotor activity was significantly decreased at doses of 122 MgAg or greater when compared to vehicle control levels. When administered doses of 168 MgAg o r greater, rats exhibited significant decrements in rotarod performance. In addition, the LD50 of tabun was determined to be 240 MgAg- Signs of cholinergic intoxication were not apparent until 144 iig/Vg tabun or more were given. Behavioral effects were thus obtained at doses that were between 54 and 71% o f t h e L D 5 0. C 1986 Society of Toxicology The organophosphorus (OP) cholinesterase-inhibiting compounds are capable of produc-ing a toxicity which can be rapid in onset, se-vere, and long-lasting (Shih, 1982). Immediate signs and symptoms include tremors, lacri-mation, salivation, convulsions and, at hig