Correspondence To

the editor: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia Elias Jabbour and colleagues reported on the novel use of intralumbar liposomal extended-release ara-C (DepoCyt; SkyePharma, San Diego, CA) administered in lieu of standard central nervous system (CNS) prophylaxis for adult patients with acute lymphocytic leukemia (ALL).1 Concerningly, 5 of the 31 patients receiving DepoCyt (16%) developed neurologic complications attributed by the inves-tigators to intralumbar DepoCyt. We would like to comment on the neurologic syndromes observed in this patient cohort and attributed to DepoCyt. In one instance, an unprovoked, uncomplicated seizure was reported. Seizures occasionally occur (more than 1%) with intra