Myocardial perfusion in compensated and failing hypertrophied left ventricle

BACHE, Myocardial perfusion. in compensated and failing hyper-trophied kft ventricle. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H534-H539,1985.-This study examined blood flow in the hypertrophied left ventricle with and without failure. Left ventricular hypertrophy was produced in 20 dogs by banding the ascending aorta at 6-7 wk of age; studies were performed after animals reached adulthood. Sixteen dogs had compen-sated hypertrophy, while four dogs had cardiac failure mani-fested by left ventricular dilatation and end-diastolic pressures X8 mmHg. The degree of hypertrophy, assessed by left ven-tricular-to-body weight ratio, was similar in animals with com-pensated hypertrophy (7.29 * 0.26 g/kg) and failure (8.45 t 0.15); both were greater than control (4.50-+ 0.15, P < 0.01). Left ventricular systolic pressure was similar in compensated hypertrophy (184 t 9 mmHg) and failure (226 * 29), as com