Sporadic Burkitt lymphoma in southern China: 12 years ’ experience in a single institution in Guangzhou

Aim To analyse the clinicopathological features of sporadic Burkitt lymphoma (sBL). Methods In a review of 1682 cases of non-Hodgkin lymphoma diagnosed in the First Affiliated Hospital and Zhongshan School of Medicine, from 1998 to 2010, 20 cases (1.2%) of sBL were identified. Histopathological examination, immunohistochemistry and in situ hybridisation were used to analyse the clinicopathological features of these cases. Results Of the 20 cases of sBL, 18 patients were male and two were female. The mean age was 18 years (range 2e67 years). Extranodal presentation was more common than nodal presentation (55 % vs 15%). Histopathologically, 18 cases (90%) showed monotonous medium-sized tumour cells, and two cases showed cells that were slightly pleomorphic in nuclear size and shape. Immunophenotypically, MUM1 was positive in three of 17 cases (17.6%). EBER expression was shown in five of 17 cases (29.4%), and all EBER-positive sBLs were Bcl-6 +/MUM1. Conclusion sBL is rare and mainly affects male children, with predominantly extranodal presentation. MUM1 expression was found in some sBLs. EBER expression was found in 29.4 % of sBLs from southern China, an area with a well-known high incidence of nasopharyngeal carcinoma, which is closely associated with EpsteineBarr virus infection