Methylprednisolone restores sensitivity to,8-adrenergic agonists in Basenji-Greyhound dogs

ergic agonists in Basenji-Greyhound dogs. J. Appl. Physiol. 72(2): 694-698, 1992.-This study investigated the effect of chronic methylprednisolone treatment on the ability of albu-terol and aminophylline to inhibit methacholine-induced air-way constriction in Basenji-Greyhound (BG) dogs in vivo. Pul-monary responsiveness to methacholine was measured in five untreated BG dogs and in the same dogs pretreated with albu-terol or aminophylline (which has been shown in this model to release endogenous catecholamines). Each dog was studied be-fore, during, and after daily subcutaneous methylprednisolone for 6 wk. Changes in pulmonary resistance and dynamic compli-ance with methacholine aerosol challenge were measured. Nei-ther baseline pulmonary function nor pulmonary responsive-ness to aerosolized methacholine was significantly altered by albuterol, aminophylline, or chronic methylprednisolone ad