Abstract: A small-scale biomechanical disc culture system was designed to stimulate intervertebral disc (IVD) ‘motion segment ’ in culture environment with load-controlled compression and combined load (compression + shear). After 7 days of diurnal mechanical loading, cell viability of discs stimulated with static compression load (0.25MPa) and static combined load (compression (0.25MPa) + shear (1.5N)) were similar (. 90 per cent) to unloaded controls. Mechanically stimulated discs showed decrease in static/dynamic moduli, early stress relaxation, and loss of disc height after 7 days of diurnal loading. Histological data of discs indicated load-induced transformations that were not apparent in controls. The feasibility of studying the mech...
Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degenerat...
The spine is routinely subjected to repetitive complex loading consisting of axial compression, tors...
Low-back pain affects 80 % of the world population at some point in their lives and 40 % of the case...
The development of mechanically active culture systems helps in understanding of the role of mechani...
Background/objectiveWhole organ in vitro intervertebral disc models have been associated with p...
SummaryBackground/ObjectiveWhole organ in vitro intervertebral disc models have been associated with...
Background: The development of mechanically active culture systems helps increase the understanding ...
Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degenerat...
Intervertebral disc degeneration is a leading cause of low back pain, a significant socioeconomic bu...
Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life fo...
Objective. To examine the effects of hydrodynamic cyclic loading on intervertebral disc cell biosynt...
STUDY DESIGN : This is a laboratory-based study examining a novel in vitro culture system for in...
Loading is important to maintain the balance of matrix turnover in the intervertebral disc (IVD). Da...
The precise mechanisms by which human intervertebral discs (IVD) respond to load remains unknown and...
The spine is routinely subjected to repetitive complex loading consisting of axial compression, tors...
Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degenerat...
The spine is routinely subjected to repetitive complex loading consisting of axial compression, tors...
Low-back pain affects 80 % of the world population at some point in their lives and 40 % of the case...
The development of mechanically active culture systems helps in understanding of the role of mechani...
Background/objectiveWhole organ in vitro intervertebral disc models have been associated with p...
SummaryBackground/ObjectiveWhole organ in vitro intervertebral disc models have been associated with...
Background: The development of mechanically active culture systems helps increase the understanding ...
Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degenerat...
Intervertebral disc degeneration is a leading cause of low back pain, a significant socioeconomic bu...
Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life fo...
Objective. To examine the effects of hydrodynamic cyclic loading on intervertebral disc cell biosynt...
STUDY DESIGN : This is a laboratory-based study examining a novel in vitro culture system for in...
Loading is important to maintain the balance of matrix turnover in the intervertebral disc (IVD). Da...
The precise mechanisms by which human intervertebral discs (IVD) respond to load remains unknown and...
The spine is routinely subjected to repetitive complex loading consisting of axial compression, tors...
Low-back pain (LBP) is a common medical complaint and associated with high societal costs. Degenerat...
The spine is routinely subjected to repetitive complex loading consisting of axial compression, tors...
Low-back pain affects 80 % of the world population at some point in their lives and 40 % of the case...