The transcription factor hypoxia-inducible factor 1 (HIF-1) has recently emerged to be a crucial regulator of the immune re-sponse following pathogen perception, including the response to the important human pathogen Pseudomonas aeruginosa. However, as mechanisms involved in HIF-1 activation by bacterial pathogens are not fully characterized, understanding how bacteria and bacterial compounds impact on HIF-1 stabilization remains a major challenge. In this context, we have focused on the effect of secreted factors of P. aeruginosa on HIF-1 regulation. Surprisingly, we found that P. aeruginosa cell-free superna-tant significantly repressed HIF-1 protein levels. Further characterization revealed that HIF-1 downregulation was dependent on a...
The quorum sensing (QS) system of Pseudomonas aeruginosa constitutes a sophisticated genome- wide ge...
Pseudomonas aeruginosa has developed a complex cell-to-cell communication system that relies on low-...
Regulation of gene expression plays a key role in bacterial adaptability to changes in the environme...
The transcription factor hypoxia-inducible factor 1 (HIF-1) has recently emerged to be a crucial reg...
The transcription factor hypoxia-inducible factor 1 (HIF-1) has recently emerged to be a crucial reg...
Pseudomonas aeruginosa causes infections in patients with compromised epithelial barrier function. M...
: Pseudomonas aeruginosa is a model quorum sensing (QS) pathogen with three interconnected QS circui...
Virulence factor production and the development of biofilms in Pseudomonas aeruginosa have been show...
Pseudomonas aeruginosa defies eradication by antibiotics and is responsible for acute and chronic hu...
Summary2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) is a quorum-sensing signal molecule used by Pseudomo...
Abstract The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in...
Bacteria synchronize group behaviors using quorum sensing, which is advantageous during an infection...
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and...
Our understanding of how the course of opportunistic bacterial infection is influenced by the microe...
<div><p>The <i>pqs</i> quorum sensing (QS) system is crucial for <i>Pseudomonas aeruginosa</i> virul...
The quorum sensing (QS) system of Pseudomonas aeruginosa constitutes a sophisticated genome- wide ge...
Pseudomonas aeruginosa has developed a complex cell-to-cell communication system that relies on low-...
Regulation of gene expression plays a key role in bacterial adaptability to changes in the environme...
The transcription factor hypoxia-inducible factor 1 (HIF-1) has recently emerged to be a crucial reg...
The transcription factor hypoxia-inducible factor 1 (HIF-1) has recently emerged to be a crucial reg...
Pseudomonas aeruginosa causes infections in patients with compromised epithelial barrier function. M...
: Pseudomonas aeruginosa is a model quorum sensing (QS) pathogen with three interconnected QS circui...
Virulence factor production and the development of biofilms in Pseudomonas aeruginosa have been show...
Pseudomonas aeruginosa defies eradication by antibiotics and is responsible for acute and chronic hu...
Summary2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) is a quorum-sensing signal molecule used by Pseudomo...
Abstract The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in...
Bacteria synchronize group behaviors using quorum sensing, which is advantageous during an infection...
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and...
Our understanding of how the course of opportunistic bacterial infection is influenced by the microe...
<div><p>The <i>pqs</i> quorum sensing (QS) system is crucial for <i>Pseudomonas aeruginosa</i> virul...
The quorum sensing (QS) system of Pseudomonas aeruginosa constitutes a sophisticated genome- wide ge...
Pseudomonas aeruginosa has developed a complex cell-to-cell communication system that relies on low-...
Regulation of gene expression plays a key role in bacterial adaptability to changes in the environme...