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Objective: Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea. Our aim was to evaluate the effect of daily zinc supplementation for 14 days on diarrhea duration, severity and morbidity in children. Methods: In a randomized, open label non-placebo controlled trial; we assessed the efficacy of providing zinc sulfate to 6 to 60 months old children with acute diarrhea for 2 weeks followed by 3 months of morbidity surveillance. Children were randomly assigned to zinc (n=150) and control (n=130) groups and received daily 15mg-30 mg elemental zinc. The trial outcomes included diarrheal duration, severity, incidence and prevalence. Results: Supplemented children had a significant improvement in plasma zinc levels by day 14 of therapy. Zinc deficiency was observed in 2.6 % of the treatment and 3.3 % of the control group. The mean duration of diarrhea after starting the supplement was 3.02 ± 2 days in the zinc group and 3.67 ± 3.2 days in the control group. There was no significant differences in the diarrhea duration by treatment group (p>0.05). The number of stools after starting the supplement on day 1 was 5.8 ± 3.7 and 5.1 ± 3.9, on day 2 was 2.9 ± 1.6 and 3.0 ± 2.2 and o