Add to ORKGAbstract: In a thorough and extensive simulation study, we investigate the practical properties of repeated confidence intervals and point estimates for the standardized dif-ference of normal means in adaptive group sequential trials. The theoretical foundations have been described in Hartung and Knapp (2009, 2010). In the simulation study, we consider an adaptive three-stage Pocock (1977)-type design for planning and showing non-inferiority and an adaptive five-stage O’Brien-Fleming (1979)-type design for planning and showing superiority
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Methods allowing unplanned adaptations to the sample size based on the interim estimate of treat-men...
In a thorough and extensive simulation study, we investigate the practical properties of repeated c...
Abstract: For studies comparing three independent arms: test group T, reference group R, and control...
Abstract: In controlled group sequential trials, we consider the ratio of normal means as the effect...
In controlled group sequential trials, we consider the ratio of normal means as the effect measure ...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
For studies comparing three independent arms: test group $T$, reference group $R$, and control grou...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
Sequential methods provide a formal framework by which clinical trial data can be monitored as they ...
This book provides an up-to-date review of the general principles of and techniques for confirmatory...
There is increasing interest in combining Phases II and III of clinical development into a single tr...
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Methods allowing unplanned adaptations to the sample size based on the interim estimate of treat-men...
In a thorough and extensive simulation study, we investigate the practical properties of repeated c...
Abstract: For studies comparing three independent arms: test group T, reference group R, and control...
Abstract: In controlled group sequential trials, we consider the ratio of normal means as the effect...
In controlled group sequential trials, we consider the ratio of normal means as the effect measure ...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
For studies comparing three independent arms: test group $T$, reference group $R$, and control grou...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
In recent years, there has been great interest in the use of adaptive features in clinical trials (i...
Sequential methods provide a formal framework by which clinical trial data can be monitored as they ...
This book provides an up-to-date review of the general principles of and techniques for confirmatory...
There is increasing interest in combining Phases II and III of clinical development into a single tr...
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Sequential methods were used to solve testing problems more efficiently. But at the same time, they ...
Methods allowing unplanned adaptations to the sample size based on the interim estimate of treat-men...