PLASMA INSULIN AND SERUM LIPIDS AND LIPOPROTEINS IN MIDDLE-AGED NON-INSULIN-DEPENDENT DIABETIC AND NON-DIABETIC SUBJECTS

E. Voutilainen, and J. Mamiemi. Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects. Am J Epidemiol 1987;125:611-21. The relationship between fasting plasma insulin and serum lipid and lipoprotein levels was studied in 1982-1983 in Kuopio, East Rnland in 225 patients with non-insulin-dependent diabetes mellitus (119 men and 106 women) and 124 non-diabetic controls (65 men and 59 women). Compared to the non-diabetic controls, diabetic subjects showed significantly lower levels of high density lipoprotein (HDL) cholesterol and high density lipoproteirij (HDL2) cholesterol and higher levels of total trtgtyceride * and very low density lipoprotein (VLDL) triglycerldes. Fasting plasma insulin correlated significantly with total triglycerides and VLDL triglycerldes and negatively with HDL cholesterol and HDL * cholesterol in both male and female diabetic subjects and non-diabetic control subjects. The corre-lation between fasting plasma Insulin and HDL cholesterol remained statistically significant in non-insulin-dependent diabetic subjects and in female non-diabeti