Editorial

Fibrinogen concentrates for post-partum haemorrhage? Do not miss the most relevant population! Post-partum haemorrhage (PPH) is an emotional clinical event leading to high morbidity and mortality in obstetrics. Among others, delayed availability of blood products has been identified as contributing to adverse outcomes. To reduce the requirements of transfusion, several newapproaches have been suggested dur-ing PPH.1 Administration of fibrinogen concentrates for preven-tion or treatment of bleeding is increasingly being supported, even if evidence-based data are still lacking.2 3 Fibrinogen has been shown to be the first coagulation factor to decrease to crit-ical levels in actively bleeding patients.4 The decrease is corre-lated with the volume of blood loss.5 The trigger level for supplementation has been increased in recent guidelines on se-vere bleeding.3 6 Clot strength increaseswith fibrinogen level ove