ORIGINAL ARTICLE pression as a Predictor of Weight Re ain Among Successful Weight Losers in Diabetes Prevention Progra D AVID w. PRICE, MD1'2

OBJECTIVE- To determine whether depression symptoms or antidepressant medication use predicts weight regain in ovetweight individuals with impaired glucose tolerance (IGT) who are successful with initial weight loss. RESEARCH DESIGN AND METHODS-A total of 1,442 panicipams who successfully lost atleast3 % of their baseline body weight after 12 months of panicipation in the randomized controlled Diabetes Prevention Program (DPP) continued in their assigned treatment group (metformin, intensive lifestyle, or placebo) and were followed into the Diabetes Prevention Pro-gram Outcome Study (DPPOS). Weight regain was defined as a return to baseline DPP body weight. Panicipant weight and antidepressant medication use were assessed every 6 months. Depression symptoms (Beck Depression Inventory [BOll score ~ 11) were assessed every 12 months. RESULTS-Only 2. 7 % of the overall cohon had moderate to severe depression symptoms at baseline; most of the panicipants with BDI score ~ 11 had only mild symptoms during the period of observation. In unadjusted analyses, both depression symptoms (hazard ratio 1.3 1 [95 % Cl 1.03-1.671. P = 0.03) and antidepressant medication use at either the previous visit (1. 72 I 1.37