Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell types and muscle tissues and focused on possible immune triggers. Methods: Expression of constitutive (PSMB5,-6,-7) and corresponding immunoproteasomal subunits (PSMB8,-9,-10) was analyzed by real-time RT-PCR in muscle biopsies and sorted peripheral blood cells of patients with IIM, non-inflammatory myopathies (NIM) and healthy donors (HD). Protein analysis in muscle biopsies was performed by western blot. Affymetrix HG-U133 platform derived tra...
This is a comprehensive review of the current knowledge on predominant immune cell phenotypes involv...
The inclusion body myositis (IBM) is the most common acquired inflammatory myopathy with an onset of...
<p>Gene expression of immunoproteasomal subunits (PSMB8–10) in CD4+, CD8+, CD19+, CD14+ and DCs of p...
OBJECTIVE: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and ...
In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulatio...
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and ...
Objective In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and u...
Idiopathic inflammatory myopathies (IIMs) are diseases with muscle weakness, morphologically charact...
The idiopathic inflammatory myopathies (IIMs) are characterized by symmetrical, proximal muscle weak...
Pathogenesis of idiopathic inflammatory myositis (IIM) involves strong interactions between dendriti...
<p>Gene expression analysis of constitutive and immunoproteasomal subunits (PSMB5–10) in muscle biop...
<p>Expression of all proteasome units were investigated in transcriptome data of muscle biopsies ref...
Idiopathic inflammatory myopathies (IIMs) are muscle diseases, characterized by inflammatory infiltr...
International audienceIntroduction: The aetiopathogenesis of juvenile dermatomyositis (JDM) remains ...
<p>Gene expression analysis of immunoproteasomal subunits (PSMB8–10) in muscle biopsies vs. CD4+, CD...
This is a comprehensive review of the current knowledge on predominant immune cell phenotypes involv...
The inclusion body myositis (IBM) is the most common acquired inflammatory myopathy with an onset of...
<p>Gene expression of immunoproteasomal subunits (PSMB8–10) in CD4+, CD8+, CD19+, CD14+ and DCs of p...
OBJECTIVE: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and ...
In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulatio...
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and ...
Objective In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and u...
Idiopathic inflammatory myopathies (IIMs) are diseases with muscle weakness, morphologically charact...
The idiopathic inflammatory myopathies (IIMs) are characterized by symmetrical, proximal muscle weak...
Pathogenesis of idiopathic inflammatory myositis (IIM) involves strong interactions between dendriti...
<p>Gene expression analysis of constitutive and immunoproteasomal subunits (PSMB5–10) in muscle biop...
<p>Expression of all proteasome units were investigated in transcriptome data of muscle biopsies ref...
Idiopathic inflammatory myopathies (IIMs) are muscle diseases, characterized by inflammatory infiltr...
International audienceIntroduction: The aetiopathogenesis of juvenile dermatomyositis (JDM) remains ...
<p>Gene expression analysis of immunoproteasomal subunits (PSMB8–10) in muscle biopsies vs. CD4+, CD...
This is a comprehensive review of the current knowledge on predominant immune cell phenotypes involv...
The inclusion body myositis (IBM) is the most common acquired inflammatory myopathy with an onset of...
<p>Gene expression of immunoproteasomal subunits (PSMB8–10) in CD4+, CD8+, CD19+, CD14+ and DCs of p...