benzydamine HCl 0.075 % in reducing post intubation sore throat

Sore throat is a frequent complication in postoperative patients under general anesthesia which is performed with endotracheal tube intubation. This effect occurs because of mucosal irritation and damage and airways inflammation due to a lubricant gel on laryngoscopy or an emphasis of endotracheal tube cuff. This study was conducted to compare the efficacy of ketamine 40 mg gargle with benzydamine HCl 0.075 % gargle in reducing post intubation of sore throat prior to the insertion of endotracheal tube. A prospective randomized double blind controlled clinical trial enrolled patients aged 18-50 years with physical status of ASA I and II who underwent elective surgery with general anesthesia in Dr. Sardjito General Hospital, Yogyakarta. Subjects were divided into 2 groups. 50 patients of group A were given 30 mL ketamine gargle 40 mg and 51 patients of group B were given 30mL benzydamine HCl gargle 0.075%. The sore throat was measured whenever the patients were fully awake, 2 hours and 4 hours post-extubation with Canbay score (no pain, mild pain, moderate pain and severe pain). There was a significant difference (p<0.01) in sore throat incidence of both groups especially at fully awake and 2 hours post-extubation; 20 % in group A versus 66.7 % in group B at fully awake and 16 % i