Background In patients with systemic sclerosis (SSc), the relationship between innate immune activation, represented by increased expression of interferon (IFN)-regulated genes, and vascular injury/activation, manifest by increased endothelin-1 (ET-1), endothelin converting enzyme-1 (ECE1) and intercellular adhesion molecule-1, is uncertain. Objective To investigate the potential roles of innate immune ligands in both these pathogenic pathways. Methods The effect of known Toll-like receptor (TLR) ligands was tested in vitro on dermal microvascular and pulmonary arterial endothelial cells, and on dermal fi broblasts cultured from healthy controls and patients with SSc. To test the effect of double-stranded RN
Copyright © 2013 Emanuele Cozzani et al. This is an open access article distributed under the Creati...
International audienceThe pathophysiology of systemic sclerosis (SSc) involves early endothelial and...
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease and accumulating evidence suggests a r...
Purpose of review Systemic sclerosis (SSc) is an autoimmune connective tissue disease in which infla...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder characterized by a pr...
Background: Consistently with their diagnostic and prognostic value, autoantibodies specific for sys...
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by three interconnected...
Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key fe...
Purpose of Review Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has define...
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the develop...
BACKGROUND/PURPOSE: Type I interferon (IFN-1) signatures are a hallmark of patients with systemic sc...
Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, i...
BACKGROUND: Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis. The re...
Pattern Recognition Receptors are critical receptors that elicit an immune response upon their activ...
Copyright © 2013 Emanuele Cozzani et al. This is an open access article distributed under the Creati...
International audienceThe pathophysiology of systemic sclerosis (SSc) involves early endothelial and...
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease and accumulating evidence suggests a r...
Purpose of review Systemic sclerosis (SSc) is an autoimmune connective tissue disease in which infla...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder characterized by a pr...
Background: Consistently with their diagnostic and prognostic value, autoantibodies specific for sys...
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by three interconnected...
Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key fe...
Purpose of Review Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has define...
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the develop...
BACKGROUND/PURPOSE: Type I interferon (IFN-1) signatures are a hallmark of patients with systemic sc...
Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, i...
BACKGROUND: Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis. The re...
Pattern Recognition Receptors are critical receptors that elicit an immune response upon their activ...
Copyright © 2013 Emanuele Cozzani et al. This is an open access article distributed under the Creati...
International audienceThe pathophysiology of systemic sclerosis (SSc) involves early endothelial and...
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease and accumulating evidence suggests a r...