Running Title: Morphine Tolerant Synapse

full-width at half maximum; HCD, higher energy collision dissociation; HSP-70, heat shock protein-70; iTRAQ, isobaric tag for relative and absolute quantitation; LRRK2, leucine-rich repeat kinase2; MALDI, matrix-assisted laser desorption/ionization; MMTS, methyl-methanethiosulfate; MS, mass spectrometry; MSN, medium spiny neuron; NEDD4, neural precursor cell expressed developmentally downregulated protein 4; PAGE, polyacrylamide gel electrophoresis; PPI, protein-protein interaction; PRE, presynaptic density; PSD, postsynaptic density; RIPK, receptor interacting serine/threonine protein kinase; RPLC, reverse phase liqui