ABSTRACT We performed a mutation accumulation (MA) experiment in the social amoeba Dictyostelium discoideum to estimate the rate and distribution of effects of spontaneous mutations affecting eight putative fitness traits. We found that the per-generation mutation rate for most fitness components is 0.0019 mutations per haploid genome per generation or larger. This rate is an order of magnitude higher than estimates for fitness components in the unicellular eukaryote Saccharomyces cerevisiae, even though the base-pair sub-stitution rate is two orders of magnitude lower. The high rate of fitness-altering mutations observed in this species may be partially explained by a large mutational target relative to S. cerevisiae. Fitness-altering muta...
The mutational process varies at many levels, from within genomes to among taxa. Many mechanisms hav...
Dictyostelium discoideum is a eukaryotic micro-organism with a unique life cycle. The amoebae live a...
The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean fitne...
We performed a mutation accumulation (MA) experiment using the social amoeba Dictyostelium discoideu...
We performed a mutation accumulation (MA) experiment in the social amoeba Dictyostelium discoideum t...
We describe the rate and spectrum of spontaneous mutations for the social amoeba Dictyostelium disco...
Part I. Mutation is the most important biological force as it generates the variation that drives ev...
Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are...
Spontaneous mutations are the source of new genetic variation and are thus central to the evolutiona...
The rate and fitness effects of new mutations have been investigated by mutation accumulation (MA) e...
Multicellular organisms regularly eliminate unfit or harmful cells in the process of normal developm...
Social groups face a fundamental problem of overcoming selfish individuals capable of destroying coo...
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rat...
The distribution of fitness effects (DFE) for new mutations is fundamental for many aspects of popul...
Knowledge of the rate and fitness effects of mutations is essential for understanding the process of...
The mutational process varies at many levels, from within genomes to among taxa. Many mechanisms hav...
Dictyostelium discoideum is a eukaryotic micro-organism with a unique life cycle. The amoebae live a...
The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean fitne...
We performed a mutation accumulation (MA) experiment using the social amoeba Dictyostelium discoideu...
We performed a mutation accumulation (MA) experiment in the social amoeba Dictyostelium discoideum t...
We describe the rate and spectrum of spontaneous mutations for the social amoeba Dictyostelium disco...
Part I. Mutation is the most important biological force as it generates the variation that drives ev...
Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are...
Spontaneous mutations are the source of new genetic variation and are thus central to the evolutiona...
The rate and fitness effects of new mutations have been investigated by mutation accumulation (MA) e...
Multicellular organisms regularly eliminate unfit or harmful cells in the process of normal developm...
Social groups face a fundamental problem of overcoming selfish individuals capable of destroying coo...
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rat...
The distribution of fitness effects (DFE) for new mutations is fundamental for many aspects of popul...
Knowledge of the rate and fitness effects of mutations is essential for understanding the process of...
The mutational process varies at many levels, from within genomes to among taxa. Many mechanisms hav...
Dictyostelium discoideum is a eukaryotic micro-organism with a unique life cycle. The amoebae live a...
The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean fitne...