Structural bioinformatics Porter: a new, accurate server for protein secondary structure prediction

Summary: Porter is a new system for protein secondary structure pre-diction in three classes. Porter relies on bidirectional recurrent neural networks with shortcut connections, accurate coding of input profiles obtained from multiple sequence alignments, second stage filtering by recurrent neural networks, incorporation of long range information and large-scale ensembles of predictors. Porter’s accuracy, tested by rig-orous 5-fold cross-validation on a large set of proteins, exceeds 79%, significantly above a copy of the state-of-the-art SSpro server, better than any system published to date. Availability: Porter is available as a public web server a