L E Results of Transsphenoidal Surgery in 35 Cases of Cushing’s Disease

his study aims at analyzing the out-comes of transsphenoidal surgery in 35 patients of Cushing’s disease (CD), the highest number of patients seen during 11 years from one center in Iran. Materials and Methods: Retrospective data from case records of all patients were retrieved. The diagnosis of CD was based on clinical presenta-tion, hormone studies, adrenal and pituitary im-aging, and thoracic imaging as and when consid-ered appropriate. Age, sex, clinical parameters, laboratory investigations, intra-operative find-ings, post-operative complications, duration of hospital stay and follow up observations were evaluated using appropriate statistical methods. Results: Of 35 patients, 26 were female and 9 male with a mean age of 28±10 years. The most frequent presenting symptom had been obesity (57%) which was present for 30±29 months. Four patients had macroadenoma and the other 31 (86%) had microadenoma. All patients were op-erated by transsphenoidal route; there were no intra-operative complications. Two patients had temporary CSF rhinorrhea and 9 had temporary diabetes insipidus in the post-operative period without any need for surgical intervention. Eight patients were lost to follow up and the remain-ing 27 were followed for 22±23 months (mini-mum 3 months and maximum 8.5 years). Remis-sion was achieved in 32 patients (88%), while the remaining 3 did not benefit from surgery. Recur-rence occurred in 3 cases (14%), requiring repeti-tion transsphenoidal surgery with success in two. Conclusion: Transsphenoidal adenomectomy is an effective modality of treatment for patients with Cushing’s disease with near zero mortality and acceptable morbidity