Add to ORKGsponse (CNAR) is associated with a long-term healthy clinical state in HIV-infected individuals. Over time CNAR is reduced concomitant with progression to disease. In studies to evaluate whether the interac-tion between CD8 cells and dendritic cells (DCs) could increase CNAR, CD8 cells from individuals who showed a de-crease in this antiviral activity were cocul-tured with monocyte-derived dendritic cells matured with CD40 ligand. After coculture with these mature DCs, the CD8 cells showed an increase in CNAR greater than that observed with CD8 cells costimulated with CD3/CD28 anti-bodies. This antiviral response appeared to be mediated primarily by production of interleukin-15 (IL-15) by the mature DCs. Purified IL-15 also enhanced CNAR,...
Interleukin-15 (IL-15) is crucial for the development of naive and memory CD8 T cells and is deliver...
Interleukin (IL)-15 regulates the proliferative activity of the CD8(+) T-cell pool in human immunode...
Amongst HIV patients with successful virological responses to antiretroviral therapy (ART), poor CD4...
Abstract: Maturation of dendritic cells (DC) to enhance their capacity to activate T cell immunity t...
<p>(A) Most CD8 T cells and almost all CD56 + CD8 T cells express the common gamma chain (γ<sub>c</s...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
An urgent need exists to devise strate-gies to augment antiviral immune re-sponses in patients with ...
A discordant response to highly active antiretroviral therapy (HAART) occurs when CD4 T cell counts ...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Hyperactivation of T cells, particularly of CD8(+) T cells, is a hallmark of chronic HIV 1 (HIV-1) i...
BACKGROUND: HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level ...
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the abilit...
Objective: To determine the functions of in vitro primed Natural Killer (NM) cells in Human Immunode...
We previously demonstrated that GM-CSF/IFN- combination allowed the differentiation of monocytes fr...
The current antiretroviral therapy has improved the clinical outcome of HIV-infected patients. Howev...
Interleukin-15 (IL-15) is crucial for the development of naive and memory CD8 T cells and is deliver...
Interleukin (IL)-15 regulates the proliferative activity of the CD8(+) T-cell pool in human immunode...
Amongst HIV patients with successful virological responses to antiretroviral therapy (ART), poor CD4...
Abstract: Maturation of dendritic cells (DC) to enhance their capacity to activate T cell immunity t...
<p>(A) Most CD8 T cells and almost all CD56 + CD8 T cells express the common gamma chain (γ<sub>c</s...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
An urgent need exists to devise strate-gies to augment antiviral immune re-sponses in patients with ...
A discordant response to highly active antiretroviral therapy (HAART) occurs when CD4 T cell counts ...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Hyperactivation of T cells, particularly of CD8(+) T cells, is a hallmark of chronic HIV 1 (HIV-1) i...
BACKGROUND: HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level ...
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the abilit...
Objective: To determine the functions of in vitro primed Natural Killer (NM) cells in Human Immunode...
We previously demonstrated that GM-CSF/IFN- combination allowed the differentiation of monocytes fr...
The current antiretroviral therapy has improved the clinical outcome of HIV-infected patients. Howev...
Interleukin-15 (IL-15) is crucial for the development of naive and memory CD8 T cells and is deliver...
Interleukin (IL)-15 regulates the proliferative activity of the CD8(+) T-cell pool in human immunode...
Amongst HIV patients with successful virological responses to antiretroviral therapy (ART), poor CD4...