The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be associated with hearing impairment, was examined using restriction fragment length poly-morphism (RFLP) analysis in two Japa-nese groups: (1) 319 unrelated SNHL outpatients (including 21 with aminogly-coside antibiotic injection history), and (2) 140 cochlear implantation patients (including 22 with aminoglycoside in-duced hearing loss). Approximately 3 % of the outpatients and 10 % of the cochlear implantation patients had the 1555A→G mutation. The frequency was higher in the patients with a history of aminoglycoside injection (outpatient group 33%, cochlear implantation group 59%). One outpatient (0.314%) had the 3243A→G mutation, but no outpa...
Abstract Sensorineural hearing impairment (SNHI) is a well-recognized manifestation of mitochondrial...
OBJECTIVE: At least 1-5 children per 1000 suffer from congenital hearing loss, and 50% of these case...
Objective: To characterize the clinical findings in a patient with hearing loss harboring an A8296G ...
Summary: The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-ind...
ABSTRACT INTRODUCTION: Several mitochondrial DNA mutations have been reported to be associated wit...
SummaryThe A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induc...
SummaryIn view of the complex mechanism of hearing, it is not difficult to understand that hearing i...
Abstract Background Variants of mitochondrial DNA (mtDNA) have been evaluated for their association ...
The ototoxic effects of aminoglycoside antibiotics are well known. A mitochondrial mutation (A1555G)...
Hearing impairment is the most prevalent sensorial deficit in the general population. Congenital dea...
AbstractIntroductionSeveral mitochondrial DNA mutations have been reported to be associated with non...
Mitochondrial mutations have previously been reported anecdotally in families with maternally inheri...
Objective: The m.1555A>G mutation in the mitochondria 12S rRNA gene has been reported as to be an im...
Mutations in mitochondrial DNA (mtDNA) have been shown to be an important cause of sensorineural hea...
Sponsorships or competing interests that may be relevant to content are dis-closed at the end of thi...
Abstract Sensorineural hearing impairment (SNHI) is a well-recognized manifestation of mitochondrial...
OBJECTIVE: At least 1-5 children per 1000 suffer from congenital hearing loss, and 50% of these case...
Objective: To characterize the clinical findings in a patient with hearing loss harboring an A8296G ...
Summary: The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-ind...
ABSTRACT INTRODUCTION: Several mitochondrial DNA mutations have been reported to be associated wit...
SummaryThe A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induc...
SummaryIn view of the complex mechanism of hearing, it is not difficult to understand that hearing i...
Abstract Background Variants of mitochondrial DNA (mtDNA) have been evaluated for their association ...
The ototoxic effects of aminoglycoside antibiotics are well known. A mitochondrial mutation (A1555G)...
Hearing impairment is the most prevalent sensorial deficit in the general population. Congenital dea...
AbstractIntroductionSeveral mitochondrial DNA mutations have been reported to be associated with non...
Mitochondrial mutations have previously been reported anecdotally in families with maternally inheri...
Objective: The m.1555A>G mutation in the mitochondria 12S rRNA gene has been reported as to be an im...
Mutations in mitochondrial DNA (mtDNA) have been shown to be an important cause of sensorineural hea...
Sponsorships or competing interests that may be relevant to content are dis-closed at the end of thi...
Abstract Sensorineural hearing impairment (SNHI) is a well-recognized manifestation of mitochondrial...
OBJECTIVE: At least 1-5 children per 1000 suffer from congenital hearing loss, and 50% of these case...
Objective: To characterize the clinical findings in a patient with hearing loss harboring an A8296G ...