pancreatic b-cell is species dependent. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E917–E924, 1998.—The capacity of 20 mM glucose to desensitize insulin release was determined. A prior exposure to 20 mM glucose impaired the response of rat islets to subsequent restimulation. Compared with control islets, insulin secretory rates measured 25–30 min after the onset of 20 mM glucose stimulation were reduced by 75%. Restimulation of glucose-desensitized islets with 20 mM glucose plus 500 nM forskolin resulted in a dramatic enhance-ment of both phases of secretion. In contrast to the desensiti-zation of rat islets induced by prior 20 mM glucose exposure, mouse islets were immune to this adverse effect of the hexose. Prior exposure to 20 mM gluc...
The present study aimed at comparing the effects of glucose on ionic and secretory events in freshly...
<p><i>A</i>: Glucagon secretion in response to 0.5 mmol/l or 11.1 mmol/l glucose in isolated islets ...
Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism...
Chronic hyperglycemia has been shown to induce either a lack of response or an increased sensitivity...
This thesis describes the relationship between glucose- and glucose dependent insulinotropic polype...
Prolonged exposure to high glucose concentration alters the expression of a set of proteins in pancr...
The aim of the present study was to clarify whether prolonged in vitro exposure of human pancreatic ...
The purpose of this study was to investigate the influence of selective denervation of the rat pancr...
Prolonged stimulation with glucose may induce desensitisation of pancreatic beta-cell function in ma...
The present study aimed at comparing the effects of glucose on ionic and secretory events in freshly...
Recent experimental contributions concerning the nature of the glucoreceptor mechanism in the B-cell...
The aim of the present study was to clarify whether prolonged in vitro exposure of human pancreatic ...
Aims/hypothesis The mechanisms by which glucose regulates glucagon release are poorly understood. Th...
Prolonged stimulation of insulin secretion by depolar-ization and Ca2 influx regularly leads to a r...
Although insulin secretion is usually regarded as a Ca2+-dependent mechanism, recent studies have su...
The present study aimed at comparing the effects of glucose on ionic and secretory events in freshly...
<p><i>A</i>: Glucagon secretion in response to 0.5 mmol/l or 11.1 mmol/l glucose in isolated islets ...
Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism...
Chronic hyperglycemia has been shown to induce either a lack of response or an increased sensitivity...
This thesis describes the relationship between glucose- and glucose dependent insulinotropic polype...
Prolonged exposure to high glucose concentration alters the expression of a set of proteins in pancr...
The aim of the present study was to clarify whether prolonged in vitro exposure of human pancreatic ...
The purpose of this study was to investigate the influence of selective denervation of the rat pancr...
Prolonged stimulation with glucose may induce desensitisation of pancreatic beta-cell function in ma...
The present study aimed at comparing the effects of glucose on ionic and secretory events in freshly...
Recent experimental contributions concerning the nature of the glucoreceptor mechanism in the B-cell...
The aim of the present study was to clarify whether prolonged in vitro exposure of human pancreatic ...
Aims/hypothesis The mechanisms by which glucose regulates glucagon release are poorly understood. Th...
Prolonged stimulation of insulin secretion by depolar-ization and Ca2 influx regularly leads to a r...
Although insulin secretion is usually regarded as a Ca2+-dependent mechanism, recent studies have su...
The present study aimed at comparing the effects of glucose on ionic and secretory events in freshly...
<p><i>A</i>: Glucagon secretion in response to 0.5 mmol/l or 11.1 mmol/l glucose in isolated islets ...
Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism...