Add to ORKGIntroduction: Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle agents, including liposomes, have shown enhanced delivery to solid tumors and brain. We compared pharmacokinetics (PK) and efficacy of PEGylated liposomal doxorubicin (PLD) with non-liposomal doxorubicin (NonL-doxo) in an intracranial model of BC. Methods: Athymic mice were inoculated intracerebrally with MDA-MB-231-BR-luciferase-expressing cells. Tumor-bearin
Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy ...
The goal of this study was to evaluate the pharmacokinetics of targeted and untargeted (111)In-doxor...
Aims: To determine how the accumulation of drug in mice bearing an extra-hepatic tumor and its thera...
Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle age...
Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle age...
Background: Metastases to the brain remain a significant hindrance to extending patient survival as ...
Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chem...
PURPOSE: PEGylated liposomes are important drug carriers that can passively target tumor by enhanced...
[[abstract]]Purpose: PEGylated liposomes are important drug carriers that can passively target tumor...
<p>(<b>A</b>) Median survival (from the time of intracranial cell line injection) of animals treated...
Purpose: PEGylated liposomes are important drug carriers that can passively target tumor by enhanced...
Yuan Ding,1,* Wei Cui,2,* Dan Sun,1 Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Jian-Hua Chen,3 Ying Xie,1...
Purpose—The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervou...
[[abstract]]PEGylated liposomes are important drug carriers for nanomedicine cancer therapy. PEGylat...
The goal of this honors project was to compare the pharmacokinetics and efficacy of PLD to small mol...
Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy ...
The goal of this study was to evaluate the pharmacokinetics of targeted and untargeted (111)In-doxor...
Aims: To determine how the accumulation of drug in mice bearing an extra-hepatic tumor and its thera...
Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle age...
Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle age...
Background: Metastases to the brain remain a significant hindrance to extending patient survival as ...
Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chem...
PURPOSE: PEGylated liposomes are important drug carriers that can passively target tumor by enhanced...
[[abstract]]Purpose: PEGylated liposomes are important drug carriers that can passively target tumor...
<p>(<b>A</b>) Median survival (from the time of intracranial cell line injection) of animals treated...
Purpose: PEGylated liposomes are important drug carriers that can passively target tumor by enhanced...
Yuan Ding,1,* Wei Cui,2,* Dan Sun,1 Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Jian-Hua Chen,3 Ying Xie,1...
Purpose—The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervou...
[[abstract]]PEGylated liposomes are important drug carriers for nanomedicine cancer therapy. PEGylat...
The goal of this honors project was to compare the pharmacokinetics and efficacy of PLD to small mol...
Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy ...
The goal of this study was to evaluate the pharmacokinetics of targeted and untargeted (111)In-doxor...
Aims: To determine how the accumulation of drug in mice bearing an extra-hepatic tumor and its thera...