Add to ORKGBackground: Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could represent an additional approach to detect low penetrance alleles. Methods: We performed a genome-wide association study comparing 1431 Sardinian patients with non-familial, BRCA1/2-mutation-negative breast cancer to 2171 healthy Sardinian blood donors. DNA was genotyped using GeneChip Human Mapping 500 K Arrays or Genome-Wide Human SNP Arrays 6.0. To increase genomic coverage, genotypes of additional SNPs were imputed using data from HapMap Phase II. After quality control filtering of genotype data, 1367 cases (9 men) and ...
Background: Genome-wide association studies (GWAS) have identified loci associated with risk of brea...
International audienceBackground: Breast cancer is the most common cancer in women worldwide. Around...
Context: There is limited evidence on how the risk of breast cancer and its subtypes depend on low-p...
BACKGROUND: Despite progress in identifying genes associated with breast cancer, many more risk loci...
Background: Despite progress in identifying genes associated with breast cancer, many more risk loci...
Journal articleBreast cancer is the most common cancer among women. Common variants at 27 loci have ...
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to ...
Breast cancer is the most common cancer in women in developed countries. To identify common breast c...
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to ...
textabstractBackground: The recent development of new high-throughput technologies for SNP genotypin...
Recently, multiple breast cancer susceptibility loci have been iden-tified by several genome-wide as...
Background: Genome-wide association studies (GWAS) have identified loci associated with risk of brea...
International audienceBackground: Breast cancer is the most common cancer in women worldwide. Around...
Context: There is limited evidence on how the risk of breast cancer and its subtypes depend on low-p...
BACKGROUND: Despite progress in identifying genes associated with breast cancer, many more risk loci...
Background: Despite progress in identifying genes associated with breast cancer, many more risk loci...
Journal articleBreast cancer is the most common cancer among women. Common variants at 27 loci have ...
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to ...
Breast cancer is the most common cancer in women in developed countries. To identify common breast c...
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to ...
textabstractBackground: The recent development of new high-throughput technologies for SNP genotypin...
Recently, multiple breast cancer susceptibility loci have been iden-tified by several genome-wide as...
Background: Genome-wide association studies (GWAS) have identified loci associated with risk of brea...
International audienceBackground: Breast cancer is the most common cancer in women worldwide. Around...
Context: There is limited evidence on how the risk of breast cancer and its subtypes depend on low-p...