Hematopathology / FLOW CYTOMETRIC IMMUNOPHENOTYPING IN POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS 24 Am J Clin Pathol 2002;117:24-28 © American Society for Clinical Pathology Flow Cytometric Immunophenotyping in Posttransplant Lymphoproliferative Disor

A b s t r a c t We studied the flow cytometric immunophenotyping (FCI) and genotypic data of 11 specimens from 10 transplant recipients and categorized them based on a scheme for posttransplant lymphoproliferative disorders (PTLDs). Specimens had been analyzed by polymerase chain reaction and/or Southern blot for T-cell and B-cell (immunoglobulin heavy chain and light chain genes) gene rearrangements (BGR). The categories for PTLDs were as follows: 1, 1; 2, 6; and 3, 4. The plasmacytic and polymorphic B-cell hyperplasias (PBCHs) revealed no monoclonal/aberrant cells by FCI or genotypic studies (GS). Three of 4 polymorphic B-cell lymphomas (PBCLs) revealed monoclonal or aberrant (no surface light chain) B cell