Green tea consumption and colorectal cancer risk: a report from the Shanghai Men’s Health Study

Tea and its constituents have demonstrated anticarcinogenic activity in both in vitro and in vivo animal studies. Results from epidemiologic studies, however, have been inconsistent. Some fac-tors that coexist with tea consumption, such as cigarette smoking, may confound or modify the association between tea consumption and cancer risk. The objective of this study was to comprehen-sively evaluate the association between green tea consumption and colorectal cancer risk in a population-based prospective cohort study, the Shanghai Men’s Health Study. The analysis included 60 567 Chinese men aged 40–74 years at baseline. During 5 years of follow-up, 243 incident cases of colorectal cancer were identified. Multivariable Cox regression models were used to es-timate hazard ratios (HRs) and 95 % confidence intervals (CIs) of developing colorectal cancer. Regular green tea consumption (ever drank green tea at least three times per week for more tha