[page 20] [Dermatology Reports 2015; 7:5749] Treatment modalities of necrobiosis lipoidica: a concise systematic review

Necrobiosis lipoidica (NL) is a rare inflam-matory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treat-ment modalities proposed and tested for this disease. A systematic review of the existing lit-erature was conducted to investigate all the available data and summarize all the clinical trials, case reports and original articles on NL. Two major databases (PubMed and Google Scholar) were used. We have examined about 70 articles. Numerous treatment modalities have been currently investigated to compare recalcitrant NL. Being rare, most of the studies regarding this disease are case reports or small-scale clinical trials. We have found that, in spite of plentiful investigations carried out during the years, there is no treatment modal-ity that has proved to be utterly satisfactory in treating NL