Correspondence Aspirin Use in Infective

To the Editor—Chan et al. [1], are to be congratulated for their prospective in-terventional study of aspirin use in pa-tients with infective endocarditis (IE). Their study did not fin that aspirin re-duced the frequency of major embolic events and showed a trend towards an in-crease in the number of major bleeding episodes in the intervention group. As ac-knowledged in their recent article [2], the initial study may have underestimated the benefi of aspirin, because the intervention was started relatively late after symptom-atic onset of IE. Thus, they carried out a post-hoc analysis of observational dat