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Thus, the articles by Schanz et al5 and by Jädersten et al8 present findings that highlight cytogenetic andmolecular insights intomech-anismsunderlying theheterogeneityofMDSand thepropensityMDS has toprogress to amore aggressive stage.Useofmore comprehensive and sensitivemethods formolecular profiling and inclusionof genetic features associated with disease prognosis in MDS classification sys-tems will likely further define critical biologic lesions that are funda-mental to this spectrum of diseases. AUTHOR’S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST Although all authors completed the disclosure declaration, the following author(s) indicated a financial or other interest that is relevant to the subject matter under consideration in this article. Certain relationships marked with a “U ” are those for which no compensation was received; those relationships marked with a “C ” were compensated. For a detailed description of the disclosure categories, or for more information about ASCO’s conflict of interest policy, please refer to the Author Disclosur