PLC-??1 and cell differentiation: An insight into myogenesis and osteogenesis

Phosphoinositide-phospholipase C-??1 (PLC-??1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-??1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and ??-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-??1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-??1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.clos