In response to genotoxic attacks, cells activate sophisticated DNA repair pathways such as nucleotide excision repair (NER), which consists of damage removal via dual incision and DNA resynthesis. Using permanganate footprinting as well as highly purified factors, we show that NER is a dynamic process that takes place in a number of successive steps during which the DNA is remodeled around the lesion in response to the various NER factors. XPC/HR23B first recognizes the damaged structure and initiates the opening of the helix from position -3 to +6. TFIIH is then recruited and, in the presence of ATP, extends the opening from position -6 to +6; it also displaces XPC downstream from the lesion, thereby providing the topological structure for...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
International audienceTo understand the mechanism of nucleotide excision repair (NER), one of the ma...
International audienceTo understand the mechanism of nucleotide excision repair (NER), one of the ma...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an ext...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a variety ...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and avoiding diseas...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
International audienceTo understand the mechanism of nucleotide excision repair (NER), one of the ma...
International audienceTo understand the mechanism of nucleotide excision repair (NER), one of the ma...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an ext...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the inv...
Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a variety ...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and avoiding diseas...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...
In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we ex...