AND YOSMTAKE, Y.: Monitoring cerebral blood flow, oxygen, glucose, lactate and ammonia metabolism: Experimental studies in animals. Circulation Research

More accurate methods for monitoring cerebral blood flow, oxygen, and glucose metabolism with results of their application in human volunteers are described. Subjects with various types of cerebral vascular disease showed decreased cerebral blood flow and oxygen and glucose metabolism but anaerobic glycolysis appeared to be increased. Inhalation of 100 % oxygen decreased anaerobic glycolysis, and mixtures of oxygen, 5 % CO2 plus oxygen, 5 % CO2 plus air, and hyperventilation all showed that cere-bral vascular reactivity is reduced in cerebrovascular disease. Nevertheless, inhala-tion of 5 % mixtures of CO2 in air or oxygen significantly increased cerebral blood flow. Inhalation of 5 % CO2 plus oxygen significantly increased cerebral oxygen consump-tion in cerebrovascular disease within 10 minutes of its institution. The depression of cerebral glucose metabolism and oxygen consumption appears to be amenable to rapid improvement in some subjects with stroke. Intravenous administration of nylidrin hydro-chloride decreased cerebral vascular resistance but did not increase cerebral blood flow or metabolism, presumably by autoregulation. Intravenous injection of 100 ml of low molecular-weight dextran increased cerebral blood flow and oxygen consumption but not to the level of statistical significance. A case of brain-stem ischemia showed a large increase of cerebral blood flow, oxygen metabolism, and glucose consumption after surgical reconstruction of the left vertebral artery accompanied by clinical recovery. Additional Indexing Words: Cerebral oxygen consumption Cerebral glucose consumptio