Ketoconazole, a broad-spectrum, antifungal drug that is administered orally, has been shown to inhibit sterol synthesis in fungi. When gynecomastia developed in some patients taking this drug, we investigated the effects of ketoconazole on steroid synthesis in humans and in isolated adrenal cells from rats. In healthy humans, the Cortisol response to adrenocorticotropic hormone was significantly blunted 4 hours after a 400-mg or 600-mg dose. The inhibition persisted for up to 8 hours and was absent by 16 hours. This finding indicated that adrenal androgen response was reduced. Easily achieved therapeutic concentrations of ketoconazole virtually eliminated corticosterone production by isolated adrenal cells from rats. Although ketoconazole a...
Recent reports described cases of severe hypertension and hypokalemia accompanied by low renin and a...
Prostate cancer is the most commonmalignancy among men in the US, with approximately 192,000 new cas...
This case describes the increased anticoagulation effect associated with the use of high-dose ketoco...
textabstractThe antifungal agent ketoconazole is often used to suppress cortisol production in patie...
to interfere with steroidogenesis in patients and rat in vitro systems. In this study we attempted t...
azole inhibits adrenal steroidogenesis; in this paper we investigated whether imidazole antimycotic ...
Ketoconazole is an imidazole derivative which is an inhibitor of adrenal steroidgenesis and is used ...
OBJECTIVE: Ketoconazole (KCZ) is an anti-fungal agent extensively used for clinical applications rel...
Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency inc...
Prolonged remission of hypercortisolism with steroidogenesis inhibitors has been described in patien...
Ketoconazole is a broad-spectrum antifungal with oral activity and is documented to block steroid bi...
Ketoconazole (KZ) is used widely for treating the superficial, systemic fungal activities and hypera...
Introduction. Posaconazole is an azole used in treatment and prophylaxis of a broad spectrum of fung...
textabstractCushing's syndrome is associated with serious morbidity and increased mortality. Irrespe...
Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoc...
Recent reports described cases of severe hypertension and hypokalemia accompanied by low renin and a...
Prostate cancer is the most commonmalignancy among men in the US, with approximately 192,000 new cas...
This case describes the increased anticoagulation effect associated with the use of high-dose ketoco...
textabstractThe antifungal agent ketoconazole is often used to suppress cortisol production in patie...
to interfere with steroidogenesis in patients and rat in vitro systems. In this study we attempted t...
azole inhibits adrenal steroidogenesis; in this paper we investigated whether imidazole antimycotic ...
Ketoconazole is an imidazole derivative which is an inhibitor of adrenal steroidgenesis and is used ...
OBJECTIVE: Ketoconazole (KCZ) is an anti-fungal agent extensively used for clinical applications rel...
Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency inc...
Prolonged remission of hypercortisolism with steroidogenesis inhibitors has been described in patien...
Ketoconazole is a broad-spectrum antifungal with oral activity and is documented to block steroid bi...
Ketoconazole (KZ) is used widely for treating the superficial, systemic fungal activities and hypera...
Introduction. Posaconazole is an azole used in treatment and prophylaxis of a broad spectrum of fung...
textabstractCushing's syndrome is associated with serious morbidity and increased mortality. Irrespe...
Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoc...
Recent reports described cases of severe hypertension and hypokalemia accompanied by low renin and a...
Prostate cancer is the most commonmalignancy among men in the US, with approximately 192,000 new cas...
This case describes the increased anticoagulation effect associated with the use of high-dose ketoco...