Immunofluorescent studies of mouse and hamster cell surface antigens induced by polyoma virus

SUMMARY-The surface antigens of mouse and hamster polyoma-induced tumor cells and of mouse cells in the lytic cycle of polyoma virus infection were studied with the indirect fluorescent-antibody technique. Sera of mice immunized with polyoma virus or polyoma tumor cells were examined. Reactions were observed between the various sera and polyoma-trans-formed mouse and hamster cells ormouse cells in the lyticcycle. No reaction was noted with normal mouse embryo cells, simian virus 40-transformed mouse or hamster cells, or with mouse cells infected with herpesvirus. In addition, control sera from mice immunized with simian virus 40, a methyl-cholanthrene-induced tumor, or a mammary tumor failed to react with the polyoma-transformed cells.-J Nat Cancer Inst 40: 263-268, 1968. VIRUS-INDUCED neoplasms in mice and ham-sters have been shown by several different immuno-logic methods to contain new antigens specific for tumors caused by the same agent. These test