Label-free fluorescent real-time monitoring of adenylyl cyclase

Rhee, Hyun-Woo
Kim, Kyoung-Shim
Han, Pyung-Lim
Hong, Jong-In

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Publication date

November 2015

DOI

10.1016/j.bmcl.2009.12.018

Publisher

Elsevier BV

ISSN

0960-894X

Journal

Bioorganic & Medicinal Chemistry Letters

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Abstract

In cellular signaling, adenylyl cyclase plays a key role in the hydrolysis of ATP to cyclic AMP and pyrophosphate. Using a synthetic fluorescent chemosensor (PyDPA) which binds strongly to the pyrophosphate group, we have developed a label-free fluorescent real-time detection system for adenylyl cyclase. This assay would be the first adenylyl cyclase assay based on chemosensing the production of pyrophosphate. (C) 2009 Elsevier Ltd. All rights reservedclose2

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Label-free fluorescent real-time monitoring of adenylyl cyclase

Abstract

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Label-free fluorescent real-time monitoring of adenylyl cyclase

Abstract

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