Among phospholipase C (PLC) isozymes (beta, gamma, delta, epsilon, zeta and eta), PLC-beta plays a key role in G-protein coupled receptor (GPCR)-mediated signaling. PLC-beta subtypes are often overlapped in their distribution, but have unique knock-out phenotypes in organism, suggesting that each subtype may have the different role even within the same type of cells. In this study, we examined the possibility of the differential coupling of each PLC-beta subtype to GPCRs, and explored the molecular mechanism underlying the specificity. Firstly, we found that PLC-beta 1 and PLC-beta 3 are activated by bradykinin (BK) or lysophosphatidic acid (LPA), respectively. BK-triggered phosphoinositides hydrolysis and subsequent Ca(2+) mobilization wer...
AbstractG protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by r...
G protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by regulatin...
Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, fo...
Among phospholipase C (PLC) isozymes (beta, gamma, delta, epsilon, zeta and eta), PLC-beta plays a k...
DoctorAmong phospholipase C (PLC) isozymes (b, g, d, e, z and h), PLC-b plays a key role in G-protei...
DoctorPhospholipase C (PLC) is a key enzyme in signal transduction by catalyzing the formation of in...
Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked...
Phospholipase C-beta isozymes that are activated by G protein-coupled receptors ( GPCR) and heterotr...
Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, fo...
Phospholipase C- isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimer...
Phospholipase C-eta 1 (PLC-eta 1) is the most recently identified PLC isotype and is primarily expre...
Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterot...
To characterize the regulatory mechanism of phospholipase C-delta 1 (PLC-delta 1) in the bradykinin ...
Chemokines and lipids signal through G-protein coupled receptors (GPCR) and regulate a variety of ph...
The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively investigated in d...
AbstractG protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by r...
G protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by regulatin...
Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, fo...
Among phospholipase C (PLC) isozymes (beta, gamma, delta, epsilon, zeta and eta), PLC-beta plays a k...
DoctorAmong phospholipase C (PLC) isozymes (b, g, d, e, z and h), PLC-b plays a key role in G-protei...
DoctorPhospholipase C (PLC) is a key enzyme in signal transduction by catalyzing the formation of in...
Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked...
Phospholipase C-beta isozymes that are activated by G protein-coupled receptors ( GPCR) and heterotr...
Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, fo...
Phospholipase C- isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimer...
Phospholipase C-eta 1 (PLC-eta 1) is the most recently identified PLC isotype and is primarily expre...
Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterot...
To characterize the regulatory mechanism of phospholipase C-delta 1 (PLC-delta 1) in the bradykinin ...
Chemokines and lipids signal through G-protein coupled receptors (GPCR) and regulate a variety of ph...
The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively investigated in d...
AbstractG protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by r...
G protein-coupled receptors (GPCRs) control a variety of fundamental cellular processes by regulatin...
Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, fo...