SHORT PAPER 221 A New Regioselective Bromination of Activated Aromatic Rings

Abstract: An efficient and highly regioselective bromination of ac-tivated aromatic rings promoted by tribromoisocyanuric acid by in situ generation of Br+ has been developed. A range of aromatic compounds were reacted with tribromoisocyanuric acid and trichloroisocyanuric acid and sodium bromide. Key words: aromatic rings, bromination, trichloroisocyanuric acid, tribromoisocyanuric acid The direct halogenation1 of aromatic rings employs halo-gens in the X2 form and generates HX, which are very tox-ic, corrosive, and polluting agents. In order to decrease toxic waste, some papers report alternative electrophilic halogenating reagents, such as N-halosuccinimides2 and N-halosaccharines,3 which are stable, easy to manipulate, and produce less toxic imides as by product. Some inter-esting methodologies for bromination of aromatic ring