of Plasmodium falciparum–Infected

The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum–infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43 % of uncomplicated malaria (), 41 % of severe malaria (), and 100%np 63 np 104 of cerebral malaria ( ; ) isolates. The mediannp 15 Pp.001 (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3–42]) than in severe (0 [0–52]) and uncomplicated (0 [0–24]) malaria (). In multivariate analyses, high parasitemia and ce-Pp.01 rebral malaria were associated independently with parasite agglutination. Plasmodium falciparum, the most virulent of the human malaria parasites, accounts for nearly all of the malaria-attributable mortality in the world. Sequestration resulting from the ad