Letters PROGRESSIVE SUPRANUCLEAR PALSY – LIKE SYNDROME INDUCED BY AMIODARONE AND FLUNARIZINE

Progressive supranuclear palsy (PSP) is a taupathy of unknown etiology, representing 7.5 % of all cases of Par-kinsonism and 50 % of atypical Parkinsonism1,2. It was first described as a clinicopathological entity by Steele, Rich-ardson and Olszewski3 in 1964. Clinically, PSP must be con-sidered in any levodopa-unresponsive parkinsonian pa-tient at middle-to-late age with progressive unexplained prominent postural instability with falls and supranuclear vertical gaze palsy1,2. The latter is characterized by limita-tion of upward, downward or lateral gaze, mainly down-ward. Other features are also important, such as: aston-ished face, retrocollis, lid freezing, monotonal speech, dis-artria, dysphagia, dementia and sloppy eaters1,2. We report a patient with signs and symptoms sugges-tive of PSP who markedly improve six months after dis