Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to a new quinolone, OPC 17116. Antimicrob. Agents Chemother

Md.) and temafloxacin (Abbott Laboratories, Chicago, Ill.) were determined by the agar dilution method and were compared with those to sparfloxacin and ofloxacin. The MICs of OPC 17116 for 90 % of Mycoplasma pneumoniae (0.25 pg/ml) and Mycoplasma hominis (0.125 pg/ml) isolates tested were closely similar to those of sparfloxacin and were four- to eightfold greater than those of ofloxacin. Temafloxacin was two- to fourfold more active than ofloxacin. Ureaplasma urealyticum was less susceptible; the MICs of OPC 17116 and temafloxacin for 90%o of isolates tested were 2 and 4.0,Lg/ml, respectively. The findings that both respiratory and genitourinary tract bacterial pathogens show increased resistance to common antimicrobial agents (10) have resulted in substantial prob-lems for antimicrobial chemotherapy and have led to a search for new antimicrobial agents. High-level resistance to such highly useful antimicrobial agents as penicillin, tetra-cyclines, and macrolides is common (10). Because of their lack of a cell wall, mycoplasmas and ureaplasmas are insusceptible to penicillins and other cell wall-specifi