Comparison of analytical methods in the determination of two venlafaxine fatalities. J Anal Toxicol

[ Abstract] Two venlafaxine (Effexor)-related eaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case I were 7.27 pg/mL venlafaxine and 5.03 pg/mL O-desmethylvenlafaxine, and Case 2 had 89.67 pg/mL venlafaxine with 3.44 pg/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented