An Inverse Relationship between the Expression of the Gastric Tumor Suppressor RUNX3 and Infection with Helicobacter pylori in Gastric

Background/Aims: This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. Methods: We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submuco-sal dissection. All tissue samples were evaluated by RUNX3 staining and subclassified by immunophenotype. H. pylori infection in dysplastic lesions and the normal surrounding tissue was examined by silver staining, and cagA status was assessed by polymerase chain reaction. Results: The loss of RUNX3 expression was observed in 62 cases (57.9%), and an association with H. pylori infection was found in 54 cases (50.5%). The infection rate with the cagA-positive H. pylori strain was 63.0%. In RUNX3-negative lesions, the rate of H. pylori infection (p=0.03) and the frequency of category 4 le-sions (according to the revised Vienna classification) were high (p=0.02). In addition, the gastric mucin phenotype wa