Rights Creative Commons: Attribution 3.0 Hong Kong License UPDATE ARTICLE Functional Dyspepsia: Recent Advances In Pathophysiology

Functional (non-ulcer) dyspepsia is a common disease. With effective treatment now available for peptic ulcer; functional dyspepsia remains a major therapeutic challenge in gastrointestinal medicine. Despite advances in technology and diagnostic methods, the "true " underlying pathogenic abnormality in this disease remains elusive. It is likely that functional dyspepsia is a heterogeneous disorder with multiple aetiological factors. In this article various pathophysiological abnormalities in functional dyspepsia are discussed, and possible aetiological mechanisms proposed. (HK Pract 1998;20:327-334