G: LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis

Objective: Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is an important novel gene associated with the proliferation and differentiation of cells. Recent studies have shown that it was overexpressed in many cancer tissues. This study investigated the associ-ation between different LAPTM4B polymorphisms and the susceptibility and prognosis of ovarian cancer. Methods: A case–control study was performed in 282 patients with ovarian cancer and 365 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all partici-pants. LAPTM4B genotypes were determined using polymerase chain reaction. Results: There was a significantly higher LAPTM4B*2 allele frequency in ovarian cancer cases than controls (P, 0.05). Using the LAPTM4B*1/1 genotype as the reference, we found that the LAPTM4B*1/2 and LAPTM4B*2/2 genotypes were positively associated with ovarian cancer. Additionally, we found a negative correlation between the tumor grade and LAPTM4B allele genotype, which indicates strongly that LAPTM4B*2 could affect the survival of patients. Conclusions: These findings indicate that the LAPTM4B*2 allele may be a risk factor for ovarian cancer and may play an important role in genetic susceptibility to ovarian cancer. Key words: ovarian cancer – LAPTM4B – polymorphism – susceptibility – prognosi